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OBJECTIVES: We analysed the current situation of public and family cord blood banks in Korea to provide the foundation for national cord blood networking system. METHODS: Surveys had sent out to 13-cord blood banks in the nation. Data were collected from 9 out of those 13 banks who replied the survey. Collected data were separated into several categories, and then preceded to comparative analysis. Each categories were as follows; the methods of collection and transportation of cord blood that are currently stored, laboratory profiles prior to storage, the system of storage, and the number of total nucleated cell (TNC) counts and CD34+ cell counts. The numerical distribution of cord blood units per TNC and CD34+ cell counts were analyzed. Also the proportion of transplantation eligible cord blood was analyzed as based on TNC counts and CD34+ cell counts per recipient's weight. RESULTS: This study confirmed the presence of 3-public cord blood banks, 3-public/family cord blood banks and 7-family cord blood banks in the country. Total of 14,497 units of cord blood were stored for public purpose (included 14,397 units of cord blood in 25~50mL volume freezer bag and 100 units of cord blood in vial) at the time of study (Jan, 2003). A number of similarities were noted in the methods of collection, transportation of cord blood and the laboratory profiles prior to storage from each bank. However, there were differences when it comes to the processing and method of storage. The HLA typing were examined by DNA analysis of either PCR-SSOP (sequence specific oligonucleotide probe) or PCR-SSP (sequence specific primer). TNC counts were found from 14,204 units (98%) of stored cord blood but the CD34+ cell counts were detected only from 3,283 units (22.6%) out of total of 14,497 units. The median number of TNC counts and CD34+ cell counts from the stored cord blood were 7.9+/-3.6x108 (1.24~71.8x108) and 2.0+/-1.9x106 (0.04~39.2x106). CONCLUSION: At present, our country keeps as much public cord bloods as foreign banks do. However, the public cord blood banks for actual patients were not facilitated well enough due to poor quality control for cord blood banks and exaggerated advertisement of family cord blood banking. This research suggests the establishment of public medical service that is led by government for the sake of public health.
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Humans , Blood Banks , Cell Count , DNA , Fetal Blood , Histocompatibility Testing , Korea , Public Health , Quality Control , TransportationABSTRACT
Thrombocytopenia and Coombs' positive hemolytic anemia (Evans syndrome) after hematopoietic stem cell transplantation (HSCT) rarely occurs, especially in childhood. We experienced a case of Evans syndrome following unmanipulated unrelated bone marrow transplantation, which promptly responded to steroid pulse therapy. Immune-mediated cytopenia should be considered for evaluation of post-engraftment cytopenia following HSCT.
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Anemia, Hemolytic , Bone Marrow Transplantation , Bone Marrow , Hematopoietic Stem Cell Transplantation , ThrombocytopeniaABSTRACT
Intensive chemotherapy with or without stem cell rescue has become widely accepted for treatment of neuroblastoma because increased dose-intensity correlates with improved response rates. For neuroblastoma that is resistant to intensive chemotherapy, further use of high-dose therapy is unlikely to be beneficial. For disease that recurs after myeloablative consolidation, high-dose salvage therapy may not be feasible because of poor bone marrow reserve and may not be justified in view of its morbidity in the absence of a realistic chance for cure. One treatment option in these difficult clinical settings is chronic oral administration of low-dose etoposide. However, there has been a few clinical reports for the experience of oral etoposide for refractory neuroblastoma. We now present 2 cases of successful response of oral etoposide for refractory neuroblastoma.
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Administration, Oral , Bone Marrow , Drug Therapy , Etoposide , Neuroblastoma , Salvage Therapy , Stem CellsABSTRACT
The ketogenic diet is a high-fat, low-protein, low-carbohydrate diet developed in the 1920s for the treatment of difficult-to-control seizures. Despite advances in both the pharmacotherapy and the surgery of epilepsy, many children continue to have difficult-to-control seizures. In this situation, a ketogenic diet should be considered as an alternative therapy. However, less attention has been paid to associated adverse events in the ketogenic diet. We report a case of infantile spasm associated with acute renal failure, lipoid pneumonitis and kwashiorkor after ketogenic diet. A better understanding of this adverse event profile will allow the pediatric neurologist to have a true informed consent discussion with the care giver when considering initiation of the ketogenic diet.
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Child , Humans , Infant , Infant, Newborn , Acute Kidney Injury , Caregivers , Diet , Drug Therapy , Epilepsy , Informed Consent , Diet, Ketogenic , Kwashiorkor , Pneumonia , Seizures , Spasms, InfantileABSTRACT
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High resolution computed tomography (CT) of the middle ear and mastoid, when properly performed and interpreted, is valuable to the otologic surgeon prior to exploration of the cholesteatomatous ear. Fifty one patients with cholesteatomatous otitis media underwent CT examination of both ears one to four weeks prior to surgery. These CT findings were then compared with operation findings. We analysed sixteen parameters of the anatomical and pathological features of the temporal bone affected by cholesteatoma. In conclusion, a high degree of correct correlation was noted between CT findings and those of the operation. Our study showed the usefulness and accuracy of preoperative computed tomographic study in cholesteatomatous otitis media.